Heart Failure Metabolism
Mitochondrial metabolism, pyruvate-lactate signaling, and mechanisms that shape cardiac hypertrophy and failure.
MD, PhD | Cardiovascular Research
Xuejing Yu
Physician-scientist advancing molecular and translational research in heart failure, atrial fibrillation, myocardial injury, mitochondrial metabolism, and RNA biomarkers.
15+
peer-reviewed articles and conference contributions
4
major U.S. research appointments after clinical training
Cardiology
from clinical practice to molecular mechanisms
Research Focus
Dr. Yu's work connects clinical cardiology with mechanistic research, using molecular biology, imaging, metabolic analysis, and data exploration to better understand heart disease.
Myocardial Injury
Cardiac ischemia/reperfusion injury, myocardial infarction models, hydrogels, and recovery after tissue damage.
RNA Biomarkers
Long noncoding RNAs, microRNAs, and gene-expression profiles linked to atrial fibrillation and chronic heart failure.
Clinical Data
Safety outcomes and event analysis in cardiovascular devices and complications, including Watchman LAA closure studies.
Experience
A research path spanning cardiology departments, medical schools, and translational cardiovascular laboratories in China and the United States.
Current
Researcher, University of Michigan Medical School
Cardiovascular research with a focus on mechanisms and translational questions in heart disease.
2021-2023
Postdoctoral Research Associate, Department of Cardiology, University of Texas Southwestern Medical Center
Studied cardiac ischemia/reperfusion, cardiac function, confocal imaging, molecular biology, and mitochondrial metabolism.
2020-2021
Postdoctoral Research Associate, Department of Cardiology, University of Pittsburgh Medical Center
Worked on microbubbles coupled with ultrasound in microthrombosis and cardiovascular injury.
2019-2020
Postdoctoral Research Associate, Department of Cardiothoracic Surgery, University of Utah School of Medicine
Investigated mitochondrial metabolism in right and left heart failure.
2017-2019
Postdoctoral Research Fellow, Department of Cardiology, Massachusetts General Hospital / Harvard University
Studied hydrogel applications in myocardial infarction and cardiovascular device outcomes using the MAUDE database.
2010-2011
Doctor, Holter Department, Fuwai Cardiological Hospital
Clinical cardiology practice at Fuwai Cardiological Hospital in Beijing.
Education
Medical and graduate training in clinical medicine and cardiology.
- 2014-2017 PhD in Cardiology, Peking University, Fifth School of Clinical Medicine
- 2011-2014 Master of Medicine in Cardiology, Chongqing Medical University
- 2005-2010 MD in Clinical Medicine, Sichuan University
- Peer Review Reviewer service for cardiovascular and medical research journals.
- Editorial Work Editorial board participation and invited editorial service across cardiology-related journals.
- Clinical Base Training and residency experience at West China Hospital and Fuwai Cardiological Hospital.
Selected Publications
Representative publications across heart failure, myocardial infarction, atrial fibrillation, cardiology devices, and adjacent biomedical research.
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
Cell Metabolism, 2021. Co-authored study on metabolic mechanisms in cardiac hypertrophy and failure.
Gelatin methacryloyl bioadhesive improves survival and reduces scar burden in myocardial infarction
Journal of the American Heart Association, 2020. Translational work on hydrogel treatment in a mouse model of MI.
Long noncoding RNAs and novel inflammatory genes in permanent atrial fibrillation
American Journal of Translational Research, 2017. First-author work using RNA sequencing in human lymphocytes.
Plasma long noncoding RNA UCA1 predicts poor prognosis in chronic heart failure patients
Medical Science Monitor, 2017. First-author study on circulating RNA as a prognostic biomarker.
MAUDE database analysis of outcomes following left atrial appendage closure
The American Journal of Cardiology, 2021. Clinical outcomes analysis for Watchman device use.
Heart failure with improved ejection fraction: the current and future in Asian populations
International Journal of Cardiology, 2022. First and corresponding-author work on HFimpEF.
Contact
Open to scientific collaboration, manuscript review, editorial service, and conversations across cardiovascular biology and translational medicine.